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Kojic Acid Dipalmitate VS Kojic Acid

Kojic Acid Dipalmitate is modified Kojic Acid derivative which not only overcomes the instability to light, heat and metallic ions, but also keeps the excellent property of inhibiting the activity of tyrosinase in the human skin and prevents the melanin forming. It is more efficacious than Kojic Acid. Kojic Dipalmitate can produce excellent effects in even toning the skin, fighting age spots, pregnancy marks, freckles as well as general skin pigmentation disorders of face and body. Unlike Kojic Acid, which often causes product stability problems such as color changes, Kojic Acid Dipalmitate offers excellent product stability without any color instability problems.

1. Skin Lightening: Kojic Acid Dipalmitate offers more efficacious skin lightening effects. Comparing with Kojic Acid, Kojic Dipalmitate markedly enhances the inhibitory effects on tyrosinase activity, which prohibits the formation of melanin. As a oilsoluble skin whitening agent, it is easier to be absorbed by skin.

2. Light and Heat Stability:Kojic Acid Dipalmitate is light and heat stable, But Kojic Acid tends to oxidize over time.

3. pH Stability: Kojic Acid Dipalmitate is stable within a wide pH range of 4-9, which provides flexibility to formulators.

4. Color Stability: Kojic Acid Dipalmitate does not turn brown or yellow over time,becuase Kojic Acid Dipalmitate is stable to pH, light, heat and oxidation, and does not complex with metal ions, which lead to color stability.

Kojic Acid Dipalmitate (KAD)is a derivate product from Kojic Acid,it is also known as Kojic Dipalmitate.Kojic Acid Dipalmitate is a popular skin-whitening agent. Before introducing Kojic Acid Dipalmitate.Kojic Acid is fermented and purified by glucose or sucrose under the action of koji. Its whitening mechanism is to inhibit both tyrosinase activity and N-DHICA oxidaSe activity. Also it can block dihydroxyindole polymerization. Kojic Acid is a rare single whitening agent that inhibits multiple enzymes simultaneously. There are Kojic Acid cream, Kojic Acid soap in the market. However,Kojic Acid uses for skin is gradually replaced by its derivatives.

Due to Kojic Acid is unstable to light, heat and metal ion. It is not easily absorbed by skin. So Kojic Acid’s derivatives came into being. Researchers have developed a number of Kojic Acid derivatives to improve performance of Kojic Acid. The derivatives not only have the same whitening mechanism as Kojic Acid, but also have better performance than Kojic Acid.The most popular Kojic Acid whitening agent currently on the market is Kojic Acid Dipalmitate (KAD). It is a diesterified derivative of Kojic Acid. It has been found that combination of KAD and glucosamine derivatives will increase skin-whitening effect.

Kojic Acid is known as 5- hydroxyl -2- hydroxymethyl -1 and 4- piranone. It is a weak acidic organic compound made by fermentation of microorganisms.Fine tramperic acid is a white or yellowish needle like crystal; easily soluble in water, alcohol and acetone, slightly soluble in ether, ethyl acetate, chloroform and pyridine, insoluble in benzene; its molecular formula is C6H6O4,Molecularweight142.1,Melting point153~156℃.

Kojic Acid is applied in the field of cosmetics. In the human skin, tyrosine is synthesized by the complex oxidation and polymerization of oxygen free radicals under the catalysis of tyrosinase, and finally the melanin is synthesized. Kojic Acid can inhibit the synthesis of tyrosinase, so it can strongly inhibit the formation of skin melanin, and it is safe and non-toxic, and will not produce leukoplakia, so Kojic has been added into the make-up water, mask, emulsion, skin cream, and can effectively treat freckles, old age spots, pigmentation, acne and other whitening cosmetics.20ug/ml.A variety of tyrosinase can be inhibited by the concentration of Kojic Acid 70 to 80% of the vitality is recommended in cosmetics, adding 0.2 to 1%.Kojic Acid is the raw material for producing maltol and ethyl maltol.In pharmaceutical,Kojic Acid has no mutagenic effect on eukaryotic cells, it can also eliminate the internal free radicals, enhance the power of the white cell, and be beneficial to the health of the human body. Therefore, Kojic Acid has already been used as the raw material of cephalosporins, and the finished product is used to treat the diseases such as headache and toothache, and the analgesic and anti-inflammatory effects are ten Divide the ideal.In agricultural field,it can be used to produce biological pesticides. The bio micro fertilizer (deep red liquid), made of 0.5 to 1% Kojic Acids, is applied to the grain and vegetable, whether it is a low concentration as a foliar fertilizer or a growth increasing agent for root application.Kojic Acid can also be used as iron analysis reagent, film speckle inhibitor, ect.

The benefits of using products containing Kojic Acid may include the following:

  • Anti-aging Effect: Products containing Kojic Acid may lighten the skin, which can improve the appearance of age spots and sun damage. The reduction of dark spots can have an anti-aging effect.
  • Treat Melasma: Kojic Acid may also be helpful in decreasing melasma, which is darkening of the skin due to pregnancy.
  • Decrease the Appearance of Scars: Kojic Acid may also reduce the discoloration of scars. Although the acid does not improve the thickness of scar tissue, it may reduce dark pigmentation associated with certain types of scars. Lightening the scar may make it less noticeable.
  • Antifungal Benefits: Kojic Acid is also thought to have some antifungal benefits. It may be helpful in preventing and treating certain fungal infections, such as athlete’s foot and yeast infections.
  • Antibacterial Effects: Kojic Acid may also provide antibacterial benefits. It may help decrease the chances of developing common types of bacterial skin infections.

Post time: Nov-26-2020