Application of Centella asiatica in cosmetics

Centella asiatica belongs to the Apiaceae family and is a perennial herb. It is a Chinese herbal plant used in many Asian countries for medicinal, dietary and cosmetic purposes. Centella asiatica contains very rich chemical components. Its main active ingredients are: triterpene saponins (triterpene saponins are formed by condensation of triterpene saponins and one or more sugar groups and/or other chemical groups. A series of natural compounds with diverse structures) such as madecassoside and madecassoside, flavonoids such as luteolin, baicalein, fisetin, vitexin, volatile oils such as caryophyllene and longifolene and method Niols, polyacetylenic alkenes.

Action and mechanism: Centella asiatica and its extracted products have anti-inflammatory, damage repair, antioxidant, anti-aging, improved skin barrier hydration, anti-scar, etc.

1. Anti-inflammation: Centella asiatica extract has a certain inhibitory effect on inflammatory reactions, so it has a certain therapeutic effect on atopic dermatitis and other diseases related to inflammatory reactions. The anti-inflammatory effect of Centella asiatica is related to its regulation of cell gene expression and its influence on the release of related cytokines.

2. Repair: The triterpene saponins of Centella asiatica have the effect of promoting wound healing. As one of the main active ingredients in Centella asiatica for treating burns and scalds, madecassic acid hydroxyasiatica may have a mechanism of action related to inhibiting lipid peroxidation and promoting Collagen synthesis is related to the inhibition of apoptosis; asiaticoside can promote wound healing by increasing the expression of cyclin B I (cyclin B I) proliferating cell nuclear antigen PCNA and inhibiting the nuclear transport of p65 protein, the main subunit of NF-KB, to inhibit inflammation. Overexpression of reaction. In addition, the hydrogel prepared from the extract of Centella asiatica and its active ingredients has good healing effect and no obvious skin toxicity.

3. Anti-oxidation and anti-aging. Centella asiatica extract has antioxidant capabilities and may be an ideal ingredient in anti-skin aging agents. , the 50% ethanol extract of Centella asiatica may inhibit oxidative damage and cell death, slow down oxidative damage to the skin, and delay skin aging by upregulating antioxidant enzyme activity and promoting fibroblasts to eliminate reactive oxygen species (ROS).

4. Improve skin barrier hydration. In addition to its anti-inflammatory and anti-aging properties, Centella asiatica extract can also be used to improve skin barrier hydration. Centella asiatica, one of the main active ingredients in Centella asiatica, can enhance skin hydration.